Primary Identifier | MGI:109350 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 20536 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables chloride:bicarbonate antiporter activity. Acts upstream of or within regulation of intracellular pH. Located in plasma membrane. Is expressed in dorsal root ganglion and nervous system. Orthologous to human SLC4A3 (solute carrier family 4 member 3). PHENOTYPE: Homozygotes for one knock-out allele show inner retina defects including selective ERG b-wave depression, optic nerve and retinal vessel anomalies, sheathing of retinal vessels and late onset photoreceptor death. Homozygotes for another knock-out allele are more sensitive to seizure-inducing agents. [provided by MGI curators] |