Primary Identifier | MGI:95811 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 14802 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within chemical postsynaptic transmission; monoatomic ion transmembrane transport; and regulation of postsynaptic membrane potential. Located in synapse. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human GRIA4 (glutamate ionotropic receptor AMPA type subunit 4). PHENOTYPE: Mice homozygous for a targeted mutation display hyperactivity, decreased thermal nociception, and abnormal sensitivity to pharmacologically induced seizures. [provided by MGI curators] |