Primary Identifier | MGI:3047328 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Cyp17a1 |
Transmission | Germline | Strain of Origin | 129X1/SvJ |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Part of exon 5 and all of exon 6 were replaced with a neo. Exon 6 contains the Ozols peptide, which comprises amino acids 346 to 366 and contains amino acids crucial for redox partner binding. Immunostaining of embryos revealed absence of protein in homozygous mutants. |