| First Author | Kasahara H | Year | 1994 |
| Journal | J Clin Invest | Volume | 94 |
| Issue | 3 | Pages | 1026-36 |
| PubMed ID | 8083344 | Mgi Jnum | J:20457 |
| Mgi Id | MGI:68545 | Doi | 10.1172/JCI117416 |
| Citation | Kasahara H, et al. (1994) Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides. J Clin Invest 94(3):1026-36 |
| abstractText | Autoimmune myocarditis is considered to play a major role in the pathogenesis of dilated cardiomyopathy. A new autoimmune myocarditis model was attained by repeated immunization using murine cardiac C-protein with the immunological adjuvant, Klebsiella pneumoniae O3 lipopolysaccharide. For further analysis of a pathological epitope, the cDNA encoding C-protein was isolated; a fusion protein encoded by part of this cDNA induced myocarditis in SMA mice as well as in three other strains: DBA/1J (H-2q), O20/A (H-2pz1), and SJL (H-2s). The nucleotide sequence and its deduced amino acid analysis revealed that this protein had immunoglobulin-like and fibronectin-like repeats. This study provides a new animal model of autoimmune myocarditis which may shed light on the pathogenesis of dilated cardiomyopathy. |
