| First Author | Burmester T | Year | 2000 |
| Journal | Nature | Volume | 407 |
| Issue | 6803 | Pages | 520-3 |
| PubMed ID | 11029004 | Mgi Jnum | J:64988 |
| Mgi Id | MGI:1891550 | Doi | 10.1038/35035093 |
| Citation | Burmester T, et al. (2000) A vertebrate globin expressed in the brain. Nature 407(6803):520-3 |
| abstractText | Haemoglobins and myoglobins constitute related protein families that function in oxygen transport and storage in humans and other vertebrates. Here we report the identification of a third globin type in man and mouse. This protein is predominantly expressed in the brain, and therefore we have called it neuroglobin. Mouse neuroglobin is a monomer with a high oxygen affinity (half saturation pressure, P50 approximately 2 torr). Analogous to myoglobin, neuroglobin may increase the availability of oxygen to brain tissue. The human neuroglobin gene (NGB), located on chromosome 14q24, has a unique exon-intron structure. Neuroglobin represents a distinct protein family that diverged early in metazoan evolution, probably before the Protostomia/Deuterostomia split. |
