| First Author | Salmon AM | Year | 2001 |
| Journal | Nat Neurosci | Volume | 4 |
| Issue | 4 | Pages | 357-8 |
| PubMed ID | 11276224 | Mgi Jnum | J:68693 |
| Mgi Id | MGI:1933070 | Doi | 10.1038/86001 |
| Citation | Salmon AM, et al. (2001) Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice. Nat Neurosci 4(4):357-8 |
| abstractText | The neuropeptide alpha CGRP (calcitonin gene-related peptide) is involved in the complex process of pain signaling, but the precise contribution of alpha CGRP remains unclear. Here we show that mice lacking alpha CGRP display an attenuated response to chemical pain and inflammation. Furthermore, alpha CGRP(-/-) mice do not show changes in heroin self-administration or morphine tolerance, but display a marked decrease in morphine withdrawal signs, suggesting an important contribution of alpha CGRP to opiate withdrawal. |
