First Author | Kennedy D | Journal | Biomed Pept Proteins Nucleic Acids |
Volume | 2 | Issue | 3 |
Pages | 93-9 | PubMed ID | 9575347 |
Mgi Jnum | J:57569 | Mgi Id | MGI:1344959 |
Citation | Kennedy D, et al. (1996) Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif. Biomed Pept Proteins Nucleic Acids 2(3):93-9 |
abstractText | Human ras-GTPase-activating protein (GAP120) SH#-domain-binding protein (G3BP) has recently been identified on the basis of its specific binding to the GAP120 SH3 binding domain. Here we report the identification of a mouse G3BP cDNA and the confirmation by three dimensional modelling of an RNA recognition motif (RRM) in the encoded protein. Mouse G3BP also contains an RGG domain, an acid-rich amino acid domain, and several SH3 domain-binding consensus sequences, indicating that mammalian G3BPs represent a new family of signal transduction proteins which connect tyrosine kinase-linked receptors to cellular RNA metabolism. |