| First Author | Faure-André G | Year | 2008 |
| Journal | Science | Volume | 322 |
| Issue | 5908 | Pages | 1705-10 |
| PubMed ID | 19074353 | Mgi Jnum | J:142244 |
| Mgi Id | MGI:3820769 | Doi | 10.1126/science.1159894 |
| Citation | Faure-Andre G, et al. (2008) Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain. Science 322(5908):1705-10 |
| abstractText | Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II-associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild-type DCs alternate between high and low motility, whereas Ii-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by Ii depended on the actin-based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space. |
