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Protein Coding Gene : Irak2 interleukin-1 receptor-associated kinase 2
Primary Identifier  MGI:2429603 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  108960
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable protein dimerization activity; protein kinase activity; and signaling adaptor activity. Acts upstream of or within lipopolysaccharide-mediated signaling pathway. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human IRAK2 (interleukin 1 receptor associated kinase 2).
PHENOTYPE: Mice homozygous for a null allele exhibit decreased susceptibility to endotoxin shock. [provided by MGI curators]
  • synonyms:
  • Irak2b,
  • MGI:2141461,
  • IRAK-2,
  • Irak2c,
  • 6330415L08Rik,
  • AI649099,
  • interleukin-1 receptor-associated kinase 2,
  • Irak2a,
  • RIKEN cDNA 6330415L08 gene,
  • MGI:1922037,
  • Irak2d,
  • expressed sequence AI649099,
  • Irak2
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1 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

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30 Pathways

Trail: ProteinCodingGene

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