| Primary Identifier | IPR030716 | Type | Family |
| Short Name | Protocadherin-19 |
| description | Protocadherin-19 (Pcdh19) belongs to the delta-2 subfamily of nonclustered protocadherins. The non-clustered PCDHs appear to have homophilic/heterophilc cell-cell adhesion properties [], and the delta-2 subfamily (comprising protocadherin-8, -10, -17, -18, and -19) is widely expressed in the nervous system [, ]. Pcdh19 is highly expressed during brain development, and could play significant roles in neuronal migration or establishment of synaptic connections. Pcdh19 mutations cause an unusual X-linked inheritance disorder resulting in epilepsy and mental retardation [, , ].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns []. |
