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Allele : Tg(UBC-scFv)2Nemz transgene insertion 2, David Nemazee
Primary Identifier  MGI:3760426 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(UBC-scFv)2Nemz
Strain of Origin  (C57BL/6 x DBA/2)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  These mice are designed to express a membrane-tethered single chain variable fragment antibody with specificity to mouse Igk light chain. The 4 kb "Ulik" transgene contained the 1.2 kb human ubiquitin C promoter, rheumatoid factor Ig light chain gene leader exon and first intron, the expressed variable genes from the rat anti-k hybridoma 187 line, the hinge, CH2, and CH3 sequences from rat gamma chain 1 (CH1 domain deleted), and the transmembrane and intracytoplasmic sequences from the H2-kb gene.
  • mutations:
  • Insertion
  • synonyms:
  • kappa-macroself,
  • Ulik,
  • kappa-macroself,
  • Ulik
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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