| First Author | Dragani TA | Year | 1995 |
| Journal | Toxicol Lett | Volume | 82-83 |
| Pages | 613-9 | PubMed ID | 8597117 |
| Mgi Jnum | J:31816 | Mgi Id | MGI:79310 |
| Doi | 10.1016/0378-4274(95)03505-2 | Citation | Dragani TA, et al. (1995) Genetics of liver tumor susceptibility in mice. Toxicol Lett 82-3:613-619 |
| abstractText | A good experimental model of genetic predisposition to hepatocellular tumors is the murine strain C3H. These tumors share morphologic similarities with human hepatocellular tumors. After a treatment with a single small dose of chemical carcinogen, the C3H mice show a high susceptibility to the growth of hepatocellular neoplastic lesions, that reach a volume >100-fold as compared to the corresponding lesions of genetically resistant strains. Genetic linkage analysis experiments were conducted in 2 different crosses, with the C3H as one of the parental strains, and the other parental strains being represented by mice genetically resistant to hepatocarcinogenesis (A/J, M. spretus). Six different regions, on chromosomes 2, 5, 7, 8, 12, and 19 showed a significant linkage with hepatocellular tumor development. These results provide the genetic basis for the strain variations seen in susceptibility to hepatocarcinogenesis, indicating polygenic inheritance of this trait. |
