| Primary Identifier | IPR044388 | Type | Domain |
| Short Name | NSP2_MERS-like |
| description | The functions of NSP2 remain unclear. SARS-CoV NSP2, rather than playing a role in viral replication, may be involved in altering the host cell environment; deletion of NSP2 from the SARS-CoV genome results in only a modest reduction in viral titers, and it has been shown to interact with two host proteins, prohibitin 1 (PHB1) and PHB2 which have been implicated in cellular functions, including cell-cycle progression, cell migration, cellular differentiation, apoptosis, and mitochondrial biogenesis [, ]. MHV NSP2, also known as p65, different from SARS-CoV NSP2, may play an important role in the viral life cycle [].This entry represents NSP2 from Middle East respiratory syndrome-related coronavirus (MERS-CoV) and betacoronaviruses in the merbecovirus subgenera (C lineage). |
