| First Author | Cosman D | Year | 1982 |
| Journal | Proc Natl Acad Sci U S A | Volume | 79 |
| Issue | 16 | Pages | 4947-51 |
| PubMed ID | 6956903 | Mgi Jnum | J:20064 |
| Mgi Id | MGI:68177 | Doi | 10.1073/pnas.79.16.4947 |
| Citation | Cosman D, et al. (1982) Tissue-specific expression of an unusual H-2 (class I)-related gene. Proc Natl Acad Sci U S A 79(16):4947-51 |
| abstractText | Sequence analysis of mouse H-2 cDNA clones has suggested the existence of an unusual class of H-2 (class I)-related antigens that, unlike the classical membrane-associated molecules, retains only the extracellular portion and is likely to be secreted. The expression of this class of H-2-related mRNA is tissue restricted; it is detectable in liver but not in brain, kidney, testis, thymus, or spleen. In the liver, its accumulation represents about one-fourth of all the H-2 (class I)-specific transcripts. This class of transcripts is present in mice of different inbred strains, but the level of expression differs markedly among them. A model is presented in which such a soluble form of the H-2 antigen would play the role of a blocking factor in maintaining peripheral inhibition of H-2 recognition. This would ensure tolerance of the H-2 molecule as a self antigen while permitting it to act as a guidance molecule for the associative recognition of viral and tumor antigens by cytotoxic T cells. |
