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Protein Coding Gene : Farp2 FERM, RhoGEF and pleckstrin domain protein 2

Primary Identifier  MGI:2385126 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  227377
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including osteoclast differentiation; podosome assembly; and regulation of integrin activation. Acts upstream of or within hair cycle process. Predicted to be located in cytoplasm. Is expressed in central nervous system; liver; retina; and testis. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit slight increase in bone volumetrics and reduced osteoclast differentiation from BMDMs cultured with M-CSF and RANKL [provided by MGI curators]
  • synonyms:
  • expressed sequence AI465173,
  • AI465173,
  • RIKEN cDNA D030026M03 gene,
  • BC009153,
  • MGI:2138267,
  • D030026M03Rik,
  • Fir,
  • MGI:2444756,
  • cDNA sequence BC009153,
  • FERM, RhoGEF and pleckstrin domain protein 2,
  • Farp2

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

10 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For