Primary Identifier | MGI:2385126 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 227377 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including osteoclast differentiation; podosome assembly; and regulation of integrin activation. Acts upstream of or within hair cycle process. Predicted to be located in cytoplasm. Is expressed in central nervous system; liver; retina; and testis. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit slight increase in bone volumetrics and reduced osteoclast differentiation from BMDMs cultured with M-CSF and RANKL [provided by MGI curators] |