| Primary Identifier | MGI:1354952 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 50781 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in negative regulation of DNA-templated transcription; negative regulation of canonical Wnt signaling pathway; and negative regulation of steroid hormone biosynthetic process. Predicted to act upstream of or within Wnt signaling pathway. Located in extracellular space. Is expressed in several structures, including brain; cardiovascular system; limb; sensory organ; and tooth. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3). PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and euthyroid but exhibit hyperactivity, a slight but significant decrease in the frequency of natural killer cells, and significantly increased IgM, hemoglobin, and hematocrit levels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
