| First Author | Wang T | Year | 2006 |
| Journal | Nat Struct Mol Biol | Volume | 13 |
| Issue | 7 | Pages | 661-2 |
| PubMed ID | 16783373 | Mgi Jnum | J:245271 |
| Mgi Id | MGI:5915408 | Doi | 10.1038/nsmb1114 |
| Citation | Wang T, et al. (2006) Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. Nat Struct Mol Biol 13(7):661-2 |
| abstractText | Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism. |
