| First Author | Strovel J | Year | 1999 |
| Journal | Cytogenet Cell Genet | Volume | 86 |
| Issue | 3-4 | Pages | 285-7 |
| PubMed ID | 10575227 | Mgi Jnum | J:174278 |
| Mgi Id | MGI:5056181 | Doi | 10.1159/000015320 |
| Citation | Strovel J, et al. (1999) Interphase FISH for rapid identification of a down syndrome animal model. Cytogenet Cell Genet 86(3-4):285-7 |
| abstractText | Mouse models of Down syndrome (trisomy 21, DS) have been developed to study the consequences of triplication of regions syntenic to distal human chromosome 21. We report a technique for the identification of segmental trisomy 16 (Ts65Dn) and diploid progeny at any age using interphase fluorescence in situ hybridization (FISH) of uncultured tail fibroblasts. Our technique is faster and less expensive than blood karyotyping. |
