| Primary Identifier | MGI:1860604 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 54195 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including Hsp90 protein binding activity; guanylate cyclase activity; and heme binding activity. Predicted to contribute to adenylate cyclase activity and cytidylate cyclase activity. Involved in cGMP-mediated signaling and trans-synaptic signaling by nitric oxide, modulating synaptic transmission. Predicted to be located in cytosol and presynaptic active zone. Predicted to be part of guanylate cyclase complex, soluble. Predicted to be active in glutamatergic synapse and presynaptic active zone cytoplasmic component. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1). PHENOTYPE: Homozygous null mice that bypass neonatal lethality die prematurely due to severe gastrointestinal obstruction and exhibit hypertension, reduced heart rate, lack of glycerol trinitrate-induced drop in systolic pressure, and lack of a nitric oxide effect on aortic relaxation and platelet aggregation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
