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Publication : Cloning and functional analysis of human p51, which structurally and functionally resembles p53.

First Author  Osada M Year  1998
Journal  Nat Med Volume  4
Issue  7 Pages  839-43
PubMed ID  9662378 Mgi Jnum  J:49001
Mgi Id  MGI:1276304 Doi  10.1038/nm0798-839
Citation  Osada M, et al. (1998) Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat Med 4(7):839-43
abstractText  The p53 tumor suppressor gene, which is induced by DNA damage and/or stress stimuli, causes cells to undergo G1-arrest or apoptotic death; thus it plays an essential role in human carcinogenesis. We have searched for p53-related genes by using degenerate PCR, and have identified two cDNA fragments similar to but distinct from p53: one previously reported, p73, and the other new. We cloned two major splicing variants of the latter gene and named these p51A and p51B (a human homologue of rat Ket). The p51A gene encodes a 448-amino-acid protein with a molecular weight of 50.9 kDa; and p51B, a 641-amino-acid protein with a molecular weight of 71.9 kDa. In contrast with the ubiquitous expression of p53, expression of p51 mRNA was found in a limited number of tissues, including skeletal muscle, placenta, mammary gland, prostate, trachea, thymus, salivary gland, uterus, heart and lung. In p53-deficient cells, p51A induced growth-suppression and apoptosis, and upregulated p21waf-1 through p53 regulatory elements. Mutations in p51 were found in some human epidermal tumors.
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