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Protein Coding Gene : Lama4 laminin, alpha 4

Primary Identifier  MGI:109321 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  16775
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable signaling receptor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within blood vessel development and brown fat cell differentiation. Located in basement membrane. Is active in neuromuscular junction and synaptic cleft. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Orthologous to human LAMA4 (laminin subunit alpha 4).
PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired motor control of the hind limbs associated with improperly positioned synaptic active zones and junctional folds, and prenatal and neonatal hemorrhages associated with capillary defects. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-38366,
  • Lama4,
  • laminin [a]4,
  • laminin, alpha 4

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

7 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For