| First Author | Azuma T | Year | 2000 |
| Journal | J Hum Genet | Volume | 45 |
| Issue | 3 | Pages | 192-5 |
| PubMed ID | 10807548 | Mgi Jnum | J:63540 |
| Mgi Id | MGI:1861155 | Doi | 10.1007/s100380050210 |
| Citation | Azuma T, et al. (2000) cDNA cloning, tissue expression, and chromosome mapping of human homolog of SOX18. J Hum Genet 45(3):192-5 |
| abstractText | The SRY (sex-determining region Y) gene encodes a transcription factor characterized by a DNA-binding motif termed the HMG (high mobility group) domain. The SOX (Sry-box) genes comprise a large family related by homology to the HMG-box region. We isolated a cDNA clone with an open reading frame encoding a putative protein of 384 amino acids, which shared 83% identity to the mouse Sox18 protein. Northern blot analysis revealed that a 1.9-kb band of human SOX18 messenger RNAs was predominantly expressed in heart, although weak signals were seen in brain, liver, testis, and leukocyte. By polymerase chain reaction (PCR)-based analyses with both a human/rodent monochromosomal hybrid cell panel and a radiation hybrid panel, the gene was mapped to the chromosome 20q13.33 region. |
