| First Author | Faverman L | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 10 | Pages | 1552-7 |
| PubMed ID | 18405667 | Mgi Jnum | J:134433 |
| Mgi Id | MGI:3785684 | Doi | 10.1016/j.febslet.2008.03.053 |
| Citation | Faverman L, et al. (2008) Extracellular transglutaminase 2 activates beta-catenin signaling in calcifying vascular smooth muscle cells. FEBS Lett 582(10):1552-7 |
| abstractText | Accumulation of transglutaminase 2 (TG2) is often associated with mineral deposits in vasculature. Here, we demonstrate that purified TG2 stimulated a 3-fold increase in matrix mineralization and up-regulation of osteoblastic markers in cultured primary vascular smooth muscle cells (VSMCs). Extracellular TG2 interacts with the low density lipoprotein related-protein 5 receptor and activates beta-catenin signaling in VSMCs. These results suggest that TG2 may promote vascular calcification by activating the beta-catenin signaling pathway. |
