| Primary Identifier | MGI:1917115 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 69865 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable enzyme-substrate adaptor activity; mRNA binding activity; and single-stranded RNA binding activity. Involved in cytidine to uridine editing. Acts upstream of or within embryo implantation; mRNA localization resulting in post-transcriptional regulation of gene expression; and mRNA modification. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; gonad; liver; and sensory organ. Human ortholog(s) of this gene implicated in gout. Orthologous to human A1CF (APOBEC1 complementation factor). PHENOTYPE: Embryos homozygous for a targeted deletion of this gene are detectable only until the blastocyst stage (E3.5) and isolated mutant blastocysts fail to proliferate in vitro. Mice homozygous for a conditional allele activated in the liver exhibit altered fructose and glycerol metabolism. Mice homozygous for a different null allele exhibit normal survival. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
