| First Author | Mori A | Year | 2006 |
| Journal | Int J Cancer | Volume | 119 |
| Issue | 12 | Pages | 2760-7 |
| PubMed ID | 16998795 | Mgi Jnum | J:117826 |
| Mgi Id | MGI:3697778 | Doi | 10.1002/ijc.22248 |
| Citation | Mori A, et al. (2006) Severe pulmonary metastasis in obese and diabetic mice. Int J Cancer 119(12):2760-7 |
| abstractText | Although obesity is known as a risk factor for several human cancers, the association of obesity with cancer recurrence and metastasis remains to be characterized. Here, B16-BL6 melanoma and Lewis lung carcinoma cells were intravenously injected into diabetic (db/db) and obese (ob/ob) mice. The number of experimental lung colonies was markedly promoted in these mice when compared with C57BL/6 mice. In contrast, tumor growth at the implanted site was comparable when cells were inoculated orthotopically. The use of B16-BL6 cells stably transfected with the luciferase gene revealed that the increased metastasis reflected a difference mainly within 6 hr after the intravenous inoculation of tumor cells. Administration of recombinant leptin in ob/ob mice abolished the increase in metastasis early on as well as the decrease in the splenic NK cell number. In addition, depletion of NK cells by an anti-asialo-GM1 antibody abrogated the enhanced metastasis in db/db mice. These results demonstrate that metastasis is markedly promoted in diabetic and obese mice mainly because of decreased NK cell function during the early phase of metastasis. |
