| First Author | Zhao Y | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 18 | Pages | 2958-64 |
| PubMed ID | 23954298 | Mgi Jnum | J:200980 |
| Mgi Id | MGI:5510605 | Doi | 10.1016/j.febslet.2013.08.005 |
| Citation | Zhao Y, et al. (2013) Inhibition effect of enteropeptidase on RANKL-RANK signalling by cleavage of RANK. FEBS Lett 587(18):2958-64 |
| abstractText | Enteropeptidase can cleave trypsinogen on the sequence of Asp-Asp-Asp-Asp-Lys and plays an important role in food digestion. The RANKL-RANK signalling pathway plays a pivotal role in bone remodelling. In this study, we reported that enteropeptidase can inhibit the RANKL-RANK signalling pathway through the cleavage of RANK. A surrogate peptide blocking assay indicated that enteropeptidase could specifically cleave RANK on the sequence NEEDK. Osteoclast differentiation assay and NF-kappaB activity assay confirmed that enteropeptidase could inhibit osteoclastogenesis in vitro through the cleavage of RANK. This is the first study to prove that the RANKL-RANK signalling pathway can be inhibited by cleavage of RANK instead of targeting RANKL. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: EPcleaveshRANK by cleavage assay (View interaction) EPcleavesmRANK by cleavage assay (View interaction). |
