| Primary Identifier | MGI:2679435 | Allele Type | Targeted |
| Attribute String | Inserted expressed sequence | Gene | Drd2 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The human IL2RA gene was inserted into exon 2 of the endogenous locus. Thet targeting construct included a polyadenylation signal and neo gene immediately downstream of IL2RA. Treatment of mutant mice with a recombinant immunotoxin consisting of the variable regions of the anti-IL2RA monoclonal antibody fused to a bacterial exotoxin results in the specific ablation of cells expressing IL2RA via the Drd2 promoter. |
