| Primary Identifier | MGI:98507 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 21414 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; gamma-delta T cell differentiation; and regulation of gamma-delta T cell differentiation. Acts upstream of or within several processes, including T cell differentiation; embryonic morphogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of euchromatin. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human TCF7 (transcription factor 7). PHENOTYPE: Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
