| First Author | Ben-Neriah Y | Year | 1986 |
| Journal | Cell | Volume | 44 |
| Issue | 4 | Pages | 577-86 |
| PubMed ID | 3512096 | Mgi Jnum | J:8189 |
| Mgi Id | MGI:56658 | Doi | 10.1016/0092-8674(86)90267-9 |
| Citation | Ben-Neriah Y, et al. (1986) Alternative 5' exons in c-abl mRNA. Cell 44(4):577-86 |
| abstractText | The cellular abl proto-oncogene encodes a protein-tyrosine kinase and is expressed in many cell types in two or three mRNA size species. Four types of mouse c-abl cDNAs have been cloned from 70Z/3 lymphoid cells that have different 5' sequences encoding predicted N-terminal regions of 20-45 amino acids. One of the four cDNAs has a predicted N-terminal sequence of met-gly-gln in common with the gag N terminus of v-abl. The 5' heterogeneity appears to be generated by alternative addition of 5' exons onto a common set of 3' exons. Alternative splicing occurs at the same site at which bcr sequences join to abl sequences in the Philadelphia chromosome translocation. |
