Primary Identifier | MGI:7546926 | Allele Type | Targeted |
Attribute String | Conditional ready, Epitope tag, No functional change | Gene | Pkhd1 |
Transmission | Germline | Strain of Origin | C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP site was inserted upstream of exon 67 and an FRT-flanked PGK-neomycin cassette and second loxP site were inserted downstream of the 3â UTR. In addition, a triple HA epitope-tag was inserted in frame at the C-terminus. The floxed region harbors the nuclear localization signal and the PC2-binding site and is a site for pathogenic mutations in humans. |