| First Author | Arnush M | Year | 1996 |
| Journal | Lab Invest | Volume | 74 |
| Issue | 6 | Pages | 985-90 |
| PubMed ID | 8667616 | Mgi Jnum | J:33492 |
| Mgi Id | MGI:80971 | Citation | Arnush M, et al. (1996) Growth factors in the regenerating pancreas of gamma-interferon transgenic mice. Lab Invest 74(6):985-90 |
| abstractText | We examined the distribution of several relevant growth factors in gamma-interferon transgenic mice, which undergo continual growth and differentiation in the pancreas. As a result, epidermal growth factor (EGF), TGF-alpha, and the EGF receptor were identified as potentially important in mediating some of these regenerative changes. Transient up-regulation of EGF, TGF-alpha, and the EGF receptor were observed in acini undergoing differentiation into duct-like structures. These ducts have been shown to proliferate and potentiate regeneration of the pancreatic islet mass. |
