| First Author | Koh DR | Year | 1994 |
| Journal | Eur J Immunol | Volume | 24 |
| Issue | 9 | Pages | 2250-3 |
| PubMed ID | 7916298 | Mgi Jnum | J:112987 |
| Mgi Id | MGI:3664165 | Doi | 10.1002/eji.1830240947 |
| Citation | Koh DR, et al. (1994) Experimental allergic encephalomyelitis (EAE) in mice lacking CD4+ T cells. Eur J Immunol 24(9):2250-3 |
| abstractText | Like most experimental autoimmune disease experimental allergic encephalomyelitis (EAE) has been shown to be mediated by CD4+ helper T cells. In vivo antibody blocking studies with anti-CD4 and adoptive transfer of activated CD4+ T cells indicate the importance of CD4+ cells in disease induction. Fourth backcross generation mutant CD4-/-PL/J mice were immunized with myelin basic protein. Despite the lack CD4+ T cells some of these mice developed EAE, albeit, at a considerably reduced frequency and with variable severity. Furthermore, antigen-specific T cell proliferation can be demonstrated, indicating some residual helper activity that is major histocompatibility complex class II restricted. This demonstrated that, although the CD4+ T cell is the prime effector cell in EAE, in mice developmentally lacking in CD4, the expanded double-negative T cells may subserve helper and effector functions. |
