| First Author | Hosokawa R | Year | 2009 |
| Journal | J Exp Zool B Mol Dev Evol | Volume | 312B |
| Issue | 4 | Pages | 343-50 |
| PubMed ID | 19235875 | Mgi Jnum | J:156255 |
| Mgi Id | MGI:4420165 | Doi | 10.1002/jez.b.21274 |
| Citation | Hosokawa R, et al. (2009) Epithelial-specific requirement of FGFR2 signaling during tooth and palate development. J Exp Zool B Mol Dev Evol 312B(4):343-50 |
| abstractText | Reciprocal interactions between epithelium and mesenchyme are crucial for embryonic development. Fibroblast growth factors (FGFs) are a growth factor family that play an important role in epithelial-mesenchymal tissue interaction. We have generated epithelial-specific conditional knockout mice targeting Fibroblast growth factor receptor 2 (Fgfr2) to investigate the function of FGF signaling during craniofacial development. K14-Cre;Fgfr2(fl/fl) mice have skin defects, retarded tooth formation, and cleft palate. During the formation of the tooth primordium and palatal processes, cell proliferation in the epithelial cells of K14-Cre;Fgfr2(fl/fl) mice is reduced. Thus, FGF signaling via FGFR2 in the epithelium is crucial for cell proliferation activity during tooth and palate development. |
