| Primary Identifier | IPR043581 | Type | Family |
| Short Name | Axin-like |
| description | This entry includes Axin-1 and Axin-2 from vertebrates and related proteins from invertebrates. Axin is a central component of the canonical Wnt signaling pathway that interacts with the adenomatous polyposis coli protein APC and the kinase GSK3beta to downregulate the effector beta-catenin []. Axin-1 (axis inhibition protein 1) is a scaffold protein that is involved in many signalling pathways, including the Wnt, transforming growth factor-beta, MAP kinase pathways, as well as p53 activation cascades [, ]. It controls many biological processes ranging from sugar intake, cell proliferation, and organ development to cell death [].Mutations in Axin-1 gene cause hepatocellular carcinoma (HCC), a primary malignant neoplasm of epithelial liver cells [], and caudal duplication anomaly (CADUA), a condition characterised by the occurrence of duplications of different organs in the caudal region [].Like its mammalian counterpart, Drosophila Axin homologue, Daxin, acts as a negative regulator of wg/Wnt signaling []. In C. elegans AXL-1 functions redundantly with its ortholog, PRY-1, in negatively regulating BAR-1/beta-catenin signaling in the developing vulva and the Q neuroblast lineage. AXL-1 also functions independently of PRY-1 in negatively regulating canonical Wnt signaling during excretory cell development []. |
