| First Author | MacDonald BT | Year | 2009 |
| Journal | Dev Cell | Volume | 17 |
| Issue | 1 | Pages | 9-26 |
| PubMed ID | 19619488 | Mgi Jnum | J:151984 |
| Mgi Id | MGI:4355654 | Doi | 10.1016/j.devcel.2009.06.016 |
| Citation | MacDonald BT, et al. (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17(1):9-26 |
| abstractText | Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. Here we review recent progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate beta-catenin stability, from Wnt receptors to the cytoplasmic beta-catenin destruction complex, and nuclear machinery that mediates beta-catenin-dependent transcription. Finally, we highlight some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis, and discuss potential therapeutic implications. |
