| Type | MGI:General | Description | 10 uM of arachidonic acid (AA) fails to inhibit apical epithelial Na+ channel (ENaC) activity in the cortical collecting duct (CCD) of mutant mice fed a high K+ (5% KCl) diet, unlike in wild-type controls where channel activity (NPo) is decreased from 1.2 +/- 0.2 to 0.3 +/- 0.1 however, addition of 100 nM 11,12-epoxyeicosatrienoic acid (11,12-EET) is still able to inhibit ENaC in the CCD of mutant mice fed a high K+ (5% KCl) diet, with NPo reduced from 2.5 +/- 0.4 to 0.2 +/- 0.1 |
