| First Author | Ali K | Year | 2004 |
| Journal | Nature | Volume | 431 |
| Issue | 7011 | Pages | 1007-11 |
| PubMed ID | 15496927 | Mgi Jnum | J:93235 |
| Mgi Id | MGI:3056271 | Doi | 10.1038/nature02991 |
| Citation | Ali K, et al. (2004) Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature 431(7011):1007-11 |
| abstractText | Inflammatory substances released by mast cells induce and maintain the allergic response. Mast cell differentiation and activation are regulated, respectively, by stem cell factor (SCF; also known as Kit ligand) and by allergen in complex with allergen-specific immunoglobulin E (IgE). Activated SCF receptors and high-affinity receptors for IgE (FcvarepsilonRI) engage phosphoinositide 3-kinases (PI(3)Ks) to generate intracellular lipid second messenger signals. Here, we report that genetic or pharmacological inactivation of the p110delta isoform of PI(3)K in mast cells leads to defective SCF-mediated in vitro proliferation, adhesion and migration, and to impaired allergen-IgE-induced degranulation and cytokine release. Inactivation of p110delta protects mice against anaphylactic allergic responses. These results identify p110delta as a new target for therapeutic intervention in allergy and mast-cell-related pathologies. |
