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Publication : Expression of Dlx genes during the development of the murine dentition.

First Author  Zhao Z Year  2000
Journal  Dev Genes Evol Volume  210
Issue  5 Pages  270-5
PubMed ID  11180832 Mgi Jnum  J:62179
Mgi Id  MGI:1858544 Doi  10.1007/s004270050314
Citation  Zhao Z, et al. (2000) Expression of Dlx genes during the development of the murine dentition. Dev Genes Evol 210(5):270-5
abstractText  The mammalian Dlx homeobox gene family has been shown to play multiple roles in tooth development, but a detailed comparison of the expression pattern of all members throughout tooth development has been lacking. We provide such an analysis for the six known murine Dlx genes. The expression patterns for these genes allow a refinement of previously proposed models for the role of Dlx genes in tooth type specification and raise the possibility of roles for subsets of these genes in tooth initiation, morphogenesis (enamel navel formation, enamel knot induction, cervical loop growth), and enamel formation. The relationship of Dlx gene expression to their genomic organization suggests coordinate regulation of linked genes at early stages but regulatory differences at later stages.
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