| First Author | Bouillet P | Year | 1997 |
| Journal | Mech Dev | Volume | 63 |
| Issue | 2 | Pages | 173-86 |
| PubMed ID | 9203140 | Mgi Jnum | J:40904 |
| Mgi Id | MGI:892623 | Doi | 10.1016/s0925-4773(97)00039-7 |
| Citation | Bouillet P, et al. (1997) Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein. Mech Dev 63(2):173-86 |
| abstractText | Retinoic acid plays important roles in development, growth and differentiation by regulating the expression of target genes. A new retinoic acid-inducible gene, Stra6, has been identified in P19 embryonal carcinoma cells using a subtractive hybridization cDNA cloning technique. Stra6 codes for a very hydrophobic membrane protein of a new type, which does not display similarities with previously characterized integral membrane proteins. Stra6, which exhibits a specific pattern of expression during development and in the adult, is strongly expressed at the level of blood-organ barriers. Interestingly, in testis Sertoli cells, Stra6 has a spermatogenic cycle-dependent expression which is lost in testes of RAR alpha null mutants where Stra6 is expressed in all tubules. We suggest that the Stra6 protein may be a component of an as yet unidentified transport machinery. |
