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Protein Coding Gene : Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial
Primary Identifier  MGI:95792 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  14719
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables L-aspartate:2-oxoglutarate aminotransferase activity. Acts upstream of or within dicarboxylic acid metabolic process. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Used to study early infantile epileptic encephalopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2).
PHENOTYPE: Homozygosity for knockout or certain in-frame deletion or missense alleles is embryonic lethal. [provided by MGI curators]
  • synonyms:
  • glutamatic-oxaloacetic transaminase 2, mitochondrial,
  • plasma membrane fatty acid binding protein,
  • MGD-MRK-10214,
  • AL022787,
  • mitochondrial aspartate aminotransferase,
  • Got-2,
  • Got2,
  • MGD-MRK-10216,
  • FABP-pm,
  • Kyat4,
  • expressed sequence AL022787,
  • mAspAT,
  • MGI:2142656
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