| First Author | Zechmeister-Machhart M | Year | 1997 |
| Journal | Gene | Volume | 186 |
| Issue | 1 | Pages | 61-6 |
| PubMed ID | 9047345 | Mgi Jnum | J:38512 |
| Mgi Id | MGI:85895 | Doi | 10.1016/s0378-1119(96)00681-6 |
| Citation | Zechmeister-Machhart M, et al. (1997) Molecular cloning and sequence analysis of the mouse protein C inhibitor gene. Gene 186(1):61-6 |
| abstractText | The gene encoding mouse protein C inhibitor (mPCI) was isolated and its nucleotide sequence determined. Alignment of the genomic sequence with that of a cDNA obtained from mouse testis revealed that the mPCI gene (like the human counterpart) is composed of five exons and four introns with highly conserved exon/intron boundaries. It encodes a pre-polypeptide of 405 amino acids, which shows 63% identity with human PCI (hPCI). The putative reactive site is identical to that of hPCI from P5 to P3', suggesting a similar protease specificity. Also the putative heparin binding sites and 'hinge' regions are highly homologous in mouse and hPCI. |
