| First Author | Harvey M | Year | 1995 |
| Journal | Nat Genet | Volume | 9 |
| Issue | 3 | Pages | 305-11 |
| PubMed ID | 7773294 | Mgi Jnum | J:23262 |
| Mgi Id | MGI:71028 | Doi | 10.1038/ng0395-305 |
| Citation | Harvey M, et al. (1995) A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nat Genet 9(3):305-11 |
| abstractText | To test the behaviour of a mutant form of p53 in the presence and absence of wild-type p53 in vivo, we mated p53-deficient mice containing a p53 null allele to transgenic mice containing multiple copies of a mutant p53 gene (Val 135). Animals hemizygous for the endogenous wild-type p53 gene with the mutant transgene exhibited accelerated tumour development and an altered tumour spectrum compared to their non-transgenic counterparts. In contrast, transgenic and non-transgenic animals nullizygous for endogenous p53 developed tumours at the same rate. Thus, the mutant Val-135 p53 allele may act in vivo in a dominant negative manner in the presence of wild-type p53 but does not display gain of function activity in the absence of wild-type p53. |
