| First Author | Riemann M | Year | 2017 |
| Journal | J Autoimmun | Volume | 81 |
| Pages | 56-67 | PubMed ID | 28385374 |
| Mgi Jnum | J:270571 | Mgi Id | MGI:6278854 |
| Doi | 10.1016/j.jaut.2017.03.007 | Citation | Riemann M, et al. (2017) Central immune tolerance depends on crosstalk between the classical and alternative NF-kappaB pathways in medullary thymic epithelial cells. J Autoimmun 81:56-67 |
| abstractText | Medullary thymic epithelial cells (mTECs) contribute to self-tolerance by expressing and presenting peripheral tissue antigens for negative selection of autoreactive T cells and differentiation of natural regulatory T cells. The molecular control of mTEC development remains incompletely understood. We here demonstrate by TEC-specific gene manipulation in mice that the NF-kappaB transcription factor subunit RelB, which is activated by the alternative NF-kappaB pathway, regulates development of mature mTECs in a dose-dependent manner. Mice with conditional deletion of Relb lacked mature mTECs and developed spontaneous autoimmunity. In addition, the NF-kappaB subunits RelA and c-Rel, which are both activated by classical NF-kappaB signaling, were jointly required for mTEC differentiation by directly regulating the transcription of Relb. Our data reveal a crosstalk mechanism between classical and alternative NF-kappaB pathways that tightly controls the development of mature mTECs to ensure self-tolerance. |
