| First Author | Gasser DL | Year | 1983 |
| Journal | Proc Natl Acad Sci U S A | Volume | 80 |
| Issue | 21 | Pages | 6620-3 |
| PubMed ID | 6356130 | Mgi Jnum | J:7228 |
| Mgi Id | MGI:55699 | Doi | 10.1073/pnas.80.21.6620 |
| Citation | Gasser DL, et al. (1983) A lymphocyte antigen encoded by a locus closely linked to H-3 on the second chromosome of the mouse. Proc Natl Acad Sci U S A 80(21):6620-3 |
| abstractText | A monoclonal antibody has been developed that recognizes a mouse lymphocyte antigen, Ly-23, that is controlled by an H-3 histocompatibility complex-linked gene on the second chromosome. Competitive binding experiments demonstrate that this antigen is distinct from the polymorphic beta 2-microglobulin antigen, which also is encoded by a gene closely linked to H-3. The strain distribution pattern differs from that of the beta 2-microglobulin polymorphism, and recombination apparently has separated the genes for these two antigens during the derivation of one recombinant inbred line. However, the R1E/TL8X line of cells, which lacks beta 2-microglobulin, is negative for the Ly-23 antigen, although the control R1.1 line is positive. The H-2 locus affects the expression of both the Ly-23 and beta 2-microglobulin antigens. |
