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Allele : H2-Ab1<b-tm1Gru> histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Michael J Grusby
Primary Identifier  MGI:2158420 Allele Type  Targeted
Attribute String  Null/knockout Gene  H2-Ab1
Transmission  Germline Strain of Origin  129S2/SvPas
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin selection cassette was inserted into exon 2. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins.
  • mutations:
  • Insertion
  • synonyms:
  • C2-,
  • Abeta<b->,
  • A<b>beta<->,
  • mII<->,
  • Ab1<tm1Gru>,
  • MHC class II-,
  • H2-Ab1<->,
  • Abeta-,
  • Abb<tm1>,
  • A<b>beta<->,
  • MHC-II-deficient,
  • IAbeta-,
  • C2-,
  • H2-Ab1<tm1Gru>,
  • I-Abeta<b->,
  • Abb-,
  • MHC-II-deficient,
  • I-A<b->,
  • Abb<tm1>,
  • Abb-,
  • Abeta-,
  • H2-Ab1<tm1Gru>,
  • I-A<b->,
  • [KO]Ab<b>,
  • [KO]Ab<b>,
  • I-Abeta<b->,
  • mII<->,
  • IAb<->,
  • IAbeta-,
  • H2-Ab1<tm1Glm>,
  • IAb<->,
  • H2-Ab1<->,
  • H2-Ab1<tm1Glm>,
  • Ab1<tm1Gru>,
  • MHC class II-,
  • Abeta<b->
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

28 Carried By

Trail: Allele

0 Driven By

325 Publication categories

Trail: Allele




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