| First Author | Stern RH | Year | 1976 |
| Journal | Biochem Genet | Volume | 14 |
| Issue | 3-4 | Pages | 373-81 |
| PubMed ID | 962848 | Mgi Jnum | J:5687 |
| Mgi Id | MGI:54164 | Doi | 10.1007/BF00484775 |
| Citation | Stern RH, et al. (1976) Strain distribution and linkage relationship of a mouse embryonic hemoglobin variant. Biochem Genet 14(3-4):373-81 |
| abstractText | Search for structural variants of three globin chains (x, y, z), synthesized only during mouse embryonic hematopoiesis, was carried out by electrophoretic analysis of blood from 12-day embryos, all with C57BL/6 mothers, and fathers from 115 inbred stocks selected for their diverse genetic origins. Structure of the beta-chains of adult hemoglobins differed among the tested strains, with 57 carrying the Hbbs allele, 56 the Hbbd allele, and two the Hbbp allele. The search revealed no x- or z-chain variants but confirmed and extended knowledge of a previously described y-chain variant. Blood of all embryos sired by males from the 57 Hbbs strains contained only y'-chains, while blood of au embryos sired by Hbbd or Hbbp males contained y2-chains as well as the y1-chains inherited from their C57BL/6 mother. The locus controlling structure of the y-chain of mouse embryonic hemoglobins is thus extremely closely linked to the locus controlling structure of adult hemoglobin beta-chain, with maximum possible recombination frequency less than 0.019. |
