| Primary Identifier | IPR038090 | Type | Homologous_superfamily |
| Short Name | Cdt1_C_WH_dom_sf |
| description | In eukaryotic replication licensing, Cdt1 plays a key role by recruiting the MCM2-7 complex onto the origin of chromosome. This entry represents the C-terminal domain of Cdt1 which is the most conserved region of Cdt1, essential for licensing and directly interacts with the MCM2-7 complex []. This region contains a WHD (winged helix domain), a typical DNA recognition motif []. The winged-helix fold is conserved throughout several other licensing factors, suggesting that they evolved from a common ancestor. In mouse Cdt1, the main role of the WH motif is to interact with MCM2-7 rather than with the DNA, as other winged-helix domains. |
