| Primary Identifier | IPR029697 | Type | Family |
| Short Name | Geminin |
| description | Geminin inhibits DNA replication by preventing the recruitment of the MCM complex to form the pre-replication complex at the origin of replication []. Geminin is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle []. Geminin can also inhibit the DNA replication licensing factor Cdt1 and regulates cell proliferation and differentiation []. Besides forming homodimers, Geminin can also form heterodimers with its homologue, Idas (also known as Multicilin) []. The Idas-Geminin heterodimer binds Cdt1 less strongly than Geminin-Geminin []. |
