| First Author | Cheng X | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 10 | Pages | 1497-503 |
| PubMed ID | 22673516 | Mgi Jnum | J:185496 |
| Mgi Id | MGI:5429082 | Doi | 10.1016/j.febslet.2012.04.005 |
| Citation | Cheng X, et al. (2012) Nemo-like kinase promotes etoposide-induced apoptosis of male germ cell-derived GC-1 cells in vitro. FEBS Lett 586(10):1497-503 |
| abstractText | Spermatogenesis is an extremely intricate process that is tightly regulated and orchestrated by a series of well-coordinated gene expression programmes. Nemo-like kinase (NLK) is an evolutionarily conserved serine/threonine kinase that functions in a wide variety of developmental events. Nevertheless, the function of NLK in spermatogenesis has not been investigated. In this study, we found that the distribution of NLK in mice exhibited a dynamic change during testicular development and gradually became concentrated in the acrosomes of elongated spermatids. NLK overexpression promoted etoposide-induced apoptosis of male germ cell-derived GC-1 cells, while knockdown of NLK by RNA interference (RNAi) attenuated etoposide-induced apoptosis. Our findings suggest that NLK plays an important role in etoposide-induced germ cell apoptosis and may be associated with spermatogenesis. |
