| First Author | Botrugno OA | Year | 2004 |
| Journal | Mol Cell | Volume | 15 |
| Issue | 4 | Pages | 499-509 |
| PubMed ID | 15327767 | Mgi Jnum | J:92508 |
| Mgi Id | MGI:3053245 | Doi | 10.1016/j.molcel.2004.07.009 |
| Citation | Botrugno OA, et al. (2004) Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol Cell 15(4):499-509 |
| abstractText | LRH-1 is an orphan nuclear receptor predominantly expressed in tissues of endodermal origin, where it controls development and cholesterol homeostasis. We show here that LRH-1 induces cell proliferation through the concomitant induction of cyclin D1 and E1, an effect that is potentiated by its interaction with beta-catenin. Whereas beta-catenin coactivates LRH-1 on the cyclin E1 promoter, LRH-1 acts as a potent tissue-restricted coactivator of beta-catenin on the cyclin D1 promoter. The implication of LRH-1 in cell proliferation highlights an unanticipated crosstalk between LRH-1 and the beta-catenin/Tcf4 signaling pathway, which is relevant for the renewal of intestinal crypt cells. |
